diff --git a/proxy/http/client.go b/proxy/http/client.go
index eba4ee7b1..0e2175a62 100644
--- a/proxy/http/client.go
+++ b/proxy/http/client.go
@@ -8,6 +8,7 @@ import (
 	"net/http"
 	"net/url"
 	"sync"
+	"time"
 
 	"golang.org/x/net/http2"
 
@@ -79,14 +80,23 @@ func (c *Client) Process(ctx context.Context, link *transport.Link, dialer inter
 	var user *protocol.MemoryUser
 	var conn internet.Connection
 
-	mbuf, _ := link.Reader.ReadMultiBuffer()
-	len := mbuf.Len()
-	firstPayload := bytespool.Alloc(len)
-	mbuf, _ = buf.SplitBytes(mbuf, firstPayload)
-	firstPayload = firstPayload[:len]
+	var firstPayload []byte
 
-	buf.ReleaseMulti(mbuf)
-	defer bytespool.Free(firstPayload)
+	if reader, ok := link.Reader.(buf.TimeoutReader); ok {
+		// 0-RTT optimization for HTTP/2: If the payload comes within 50 ms, it can be
+		// transmitted together. Note we should not get stuck here, as the payload may
+		// not exist (considering to access MySQL database via a HTTP proxy, where the
+		// server sends hello to the client first).
+		if mbuf, _ := reader.ReadMultiBufferTimeout(50 * time.Millisecond); mbuf != nil {
+			mlen := mbuf.Len()
+			firstPayload = bytespool.Alloc(mlen)
+			mbuf, _ = buf.SplitBytes(mbuf, firstPayload)
+			firstPayload = firstPayload[:mlen]
+
+			buf.ReleaseMulti(mbuf)
+			defer bytespool.Free(firstPayload)
+		}
+	}
 
 	if err := retry.ExponentialBackoff(5, 100).On(func() error {
 		server := c.serverPicker.PickServer()