diff --git a/gnu/packages/scheme.scm b/gnu/packages/scheme.scm
index e7cf95021f..8d3ca33413 100644
--- a/gnu/packages/scheme.scm
+++ b/gnu/packages/scheme.scm
@@ -408,46 +408,73 @@ implementation techniques and as an expository tool.")
     (build-system gnu-build-system)
     (arguments
      '(#:phases
-       (let* ((gui-libs
-               (lambda (inputs)
-                 (define (lib input)
-                   (string-append (assoc-ref inputs input) "/lib"))
-
-                 (list (lib "glib")
-                       (lib "cairo")
-                       (lib "pango")
-                       (lib "libjpeg")
-                       (lib "gtk")
-                       (lib "gdk-pixbuf")
-                       (lib "fontconfig")
-                       (lib "sqlite")))))         ;to build the doc
-         (alist-cons-before
-          'configure 'pre-configure
-          (lambda* (#:key inputs #:allow-other-keys)
-            (chdir "src")
-
-            ;; The GUI libs are dynamically opened through the FFI, so they
-            ;; must be in the loader's search path.
-            (setenv "LD_LIBRARY_PATH" (string-join (gui-libs inputs) ":")))
-          (alist-cons-after
-           'unpack 'patch-/bin/sh
-           (lambda _
-             (substitute* "collects/racket/system.rkt"
-               (("/bin/sh") (which "sh"))))
-           (alist-cons-after
-            'install 'wrap-programs
-            (lambda* (#:key inputs outputs #:allow-other-keys)
-              (let ((out (assoc-ref outputs "out")))
-                (define (wrap prog)
-                  (wrap-program prog
-                                `("LD_LIBRARY_PATH" ":" prefix
-                                  ,(gui-libs inputs))))
-
-                (with-directory-excursion (string-append out "/bin")
-                  (for-each wrap
-                            (list "gracket" "drracket" "slideshow" "mred"))
-                  #t)))
-            %standard-phases))))
+       (alist-cons-before
+        'configure 'pre-configure
+        (lambda* (#:key inputs #:allow-other-keys)
+          ;; Patch dynamically loaded libraries with their absolute paths.
+          (let* ((library-path   (search-path-as-string->list
+                                  (getenv "LIBRARY_PATH")))
+                 (find-so        (lambda (soname)
+                                   (search-path
+                                    library-path
+                                    (format #f "~a.so" soname))))
+                 (patch-ffi-libs (lambda (file libs)
+                                   (for-each
+                                    (lambda (lib)
+                                      (substitute* file
+                                        (((format #f "\"~a\"" lib))
+                                         (format #f "\"~a\"" (find-so lib)))))
+                                    libs))))
+            (substitute* "collects/db/private/sqlite3/ffi.rkt"
+              (("ffi-lib sqlite-so")
+               (format #f "ffi-lib \"~a\"" (find-so "libsqlite3"))))
+            (substitute* "collects/openssl/libssl.rkt"
+              (("ffi-lib libssl-so")
+               (format #f "ffi-lib \"~a\"" (find-so "libssl"))))
+            (substitute* "collects/openssl/libcrypto.rkt"
+              (("ffi-lib libcrypto-so")
+               (format #f "ffi-lib \"~a\"" (find-so "libcrypto"))))
+            (substitute* "share/pkgs/math-lib/math/private/bigfloat/gmp.rkt"
+              (("ffi-lib libgmp-so")
+               (format #f "ffi-lib \"~a\"" (find-so "libgmp"))))
+            (substitute* "share/pkgs/math-lib/math/private/bigfloat/mpfr.rkt"
+              (("ffi-lib libmpfr-so")
+               (format #f "ffi-lib \"~a\"" (find-so "libmpfr"))))
+            (for-each
+             (lambda (x) (apply patch-ffi-libs x))
+             '(("share/pkgs/draw-lib/racket/draw/unsafe/cairo-lib.rkt"
+                ("libfontconfig" "libcairo"))
+               ("share/pkgs/draw-lib/racket/draw/unsafe/glib.rkt"
+                ("libglib-2.0" "libgmodule-2.0" "libgobject-2.0"))
+               ("share/pkgs/draw-lib/racket/draw/unsafe/jpeg.rkt"
+                ("libjpeg"))
+               ("share/pkgs/draw-lib/racket/draw/unsafe/pango.rkt"
+                ("libpango-1.0" "libpangocairo-1.0"))
+               ("share/pkgs/draw-lib/racket/draw/unsafe/png.rkt"
+                ("libpng"))
+               ("share/pkgs/db-lib/db/private/odbc/ffi.rkt"
+                ("libodbc"))
+               ("share/pkgs/gui-lib/mred/private/wx/gtk/x11.rkt"
+                ("libX11"))
+               ("share/pkgs/gui-lib/mred/private/wx/gtk/gsettings.rkt"
+                ("libgio-2.0"))
+               ("share/pkgs/gui-lib/mred/private/wx/gtk/gtk3.rkt"
+                ("libgdk-3" "libgtk-3"))
+               ("share/pkgs/gui-lib/mred/private/wx/gtk/unique.rkt"
+                ("libunique-1.0"))
+               ("share/pkgs/gui-lib/mred/private/wx/gtk/utils.rkt"
+                ("libgdk-x11-2.0" "libgdk_pixbuf-2.0" "libgtk-x11-2.0"))
+               ("share/pkgs/gui-lib/mred/private/wx/gtk/gl-context.rkt"
+                ("libGL"))
+               ("share/pkgs/sgl/gl.rkt"
+                ("libGL" "libGLU")))))
+          (chdir "src"))
+        (alist-cons-after
+         'unpack 'patch-/bin/sh
+         (lambda _
+           (substitute* "collects/racket/system.rkt"
+             (("/bin/sh") (which "sh"))))
+         %standard-phases))
        #:tests? #f                                ; XXX: how to run them?
        ))
     (inputs `(("libffi" ,libffi)