diff --git a/gnu/packages/game-development.scm b/gnu/packages/game-development.scm
index 2a58848dce..40807450ea 100644
--- a/gnu/packages/game-development.scm
+++ b/gnu/packages/game-development.scm
@@ -1484,6 +1484,57 @@ visual novels, while its Python scripting is enough for complex simulation
 games.")
     (license license:expat)))
 
+(define-public python-pyxel
+  (package
+    (name "python-pyxel")
+    (version "1.4.3")
+    (source
+     (origin
+       (method git-fetch)
+       (uri
+        (git-reference
+         (url "https://github.com/kitao/pyxel")
+         (commit (string-append "v" version))))
+       (file-name (git-file-name name version))
+       (sha256
+        (base32
+         "0bwsgb5yq5s479cnf046v379zsn5ybp5195kbfvzr9l11qbaicm9"))
+       (modules '((guix build utils)))
+       (snippet
+        '(begin
+           (delete-file-recursively "pyxel/core/bin")))))
+    (build-system python-build-system)
+    (arguments
+     `(#:tests? #f ; "Tests" are actually example programs that never halt.
+       #:phases
+       (modify-phases %standard-phases
+         (add-after 'unpack 'patch-build-files
+           (lambda* (#:key inputs #:allow-other-keys)
+             (substitute* "setup.py"
+               (("\"pyxel\\.core\\.bin\\.(.*)\"," all arch)
+                (if (string=? arch "linux")
+                    all
+                    "")))
+             (substitute* "pyxel/core/Makefile"
+               (("`sdl2-config")
+                (string-append "`sdl2-config --prefix="
+                               (assoc-ref inputs "sdl2"))))))
+         (add-before 'build 'prebuild
+           (lambda _
+             (invoke "make" "-C" "pyxel/core"))))))
+    (inputs
+     `(("gifsicle" ,gifsicle)
+       ("sdl2" ,(sdl-union (list sdl2 sdl2-image)))))
+    (native-inputs
+     `(("gcc" ,gcc-10)))                  ; for std::filesystem
+    (home-page "https://github.com/kitao/pyxel")
+    (synopsis "Retro game engine for Python")
+    (description "Pyxel is a game engine inspired by retro gaming consoles.
+It has a fixed 16-color palette, can hold up to 3 image banks and 8 tilemaps
+(256x256 pixels each) and 4 sound channels with 64 definable sounds.  It
+also comes with a built-in image and sound editor.")
+    (license license:expat)))
+
 (define-public grafx2
   (package
     (name "grafx2")