diff --git a/gnu/packages/bioconductor.scm b/gnu/packages/bioconductor.scm
index ec0fae9cbb..ae9e9fe08c 100644
--- a/gnu/packages/bioconductor.scm
+++ b/gnu/packages/bioconductor.scm
@@ -4517,13 +4517,13 @@ mechanism based on the shared signatures.")
 (define-public r-decomptumor2sig
   (package
     (name "r-decomptumor2sig")
-    (version "2.14.0")
+    (version "2.16.0")
     (source (origin
               (method url-fetch)
               (uri (bioconductor-uri "decompTumor2Sig" version))
               (sha256
                (base32
-                "0agvmgwyk458lhhhspd8243n4897f0q7jf9yqhwsl5wi8011vmqd"))))
+                "028sczy1d108i05ymr1wpj6jdrcds476wbmmc7rzzflzyg4aix75"))))
     (properties `((upstream-name . "decompTumor2Sig")))
     (build-system r-build-system)
     (inputs (list perl))                ;script/extractSpecColumns.pl