diff --git a/gnu/packages/samba.scm b/gnu/packages/samba.scm
index da103ed839..e09acf49f9 100644
--- a/gnu/packages/samba.scm
+++ b/gnu/packages/samba.scm
@@ -9,7 +9,7 @@
 ;;; Copyright © 2018 Ricardo Wurmus <rekado@elephly.net>
 ;;; Copyright © 2019 Rutger Helling <rhelling@mykolab.com>
 ;;; Copyright © 2020 Pierre Langlois <pierre.langlois@gmx.com>
-;;; Copyright © 2020, 2022 Maxim Cournoyer <maxim.cournoyer@gmail.com>
+;;; Copyright © 2020, 2022, 2023 Maxim Cournoyer <maxim.cournoyer@gmail.com>
 ;;; Copyright © 2022 Jean-Pierre De Jesus DIAZ <me@jeandudey.tech>
 ;;; Copyright © 2022 Guillaume Le Vaillant <glv@posteo.net>
 ;;; Copyright © 2022 Maxime Devos <maximedevos@telenet.be>
@@ -206,7 +206,11 @@ external dependencies.")
             (lambda* (#:key inputs #:allow-other-keys)
               (let* ((libdir (string-append #$output "/lib")))
                 (invoke "./configure"
-                        "--enable-selftest"
+                        #$@(if (member (%current-system)
+                                       (package-transitive-supported-systems
+                                        python-cryptography))
+                               '("--enable-selftest")
+                               '())
                         "--enable-fhs"
                         (string-append "--prefix=" #$output)
                         "--sysconfdir=/etc"
@@ -250,19 +254,27 @@ external dependencies.")
      ;; In Requires or Requires.private of pkg-config files.
      (list ldb talloc tevent))
     (native-inputs
-     (list perl-parse-yapp
-           pkg-config
-           python-cryptography          ;for krb5 tests
-           python-dnspython
-           python-iso8601
-           python-markdown
-           rpcsvc-proto                 ;for 'rpcgen'
-           python-pyasn1                ;for krb5 tests
-           ;; For generating man pages.
-           docbook-xml-4.2
-           docbook-xsl-next             ;otherwise the man pages are corrupted
-           libxslt
-           libxml2))                    ;for XML_CATALOG_FILES
+     (append
+      (list perl-parse-yapp
+            pkg-config)
+      ;; The python-cryptography dependency is needed for the krb5 tests.
+      ;; Since python-cryptography requires Rust, add it conditionally
+      ;; depending on such support.
+      (if (member (%current-system)
+                  (package-transitive-supported-systems
+                   python-cryptography))
+          (list python-cryptography)
+          '())
+      (list python-dnspython
+            python-iso8601
+            python-markdown
+            rpcsvc-proto                ;for 'rpcgen'
+            python-pyasn1               ;for krb5 tests
+            ;; For generating man pages.
+            docbook-xml-4.2
+            docbook-xsl-next            ;otherwise the man pages are corrupted
+            libxslt
+            libxml2)))                  ;for XML_CATALOG_FILES
     (home-page "https://www.samba.org/")
     (synopsis
      "The standard Windows interoperability suite of programs for GNU and Unix")
@@ -291,20 +303,31 @@ Desktops into Active Directory environments using the winbind daemon.")
                             "samba-" version ".tar.gz"))
         (sha256
          (base32 "1nrp85aya0pbbqdqjaqcw82cnzzys16yls37hi2h6mci8d09k4si"))))
+     ;; Note: this is duplicated from samba for robustness annd because
+     ;; docbook-xsl (rather than docbook-xsl-next) is used.
      (native-inputs
-      (list perl-parse-yapp
-            pkg-config
-            python-cryptography         ;for krb5 tests
-            python-dnspython
-            python-iso8601
-            python-markdown
-            rpcsvc-proto                ;for 'rpcgen'
-            python-pyasn1               ;for krb5 tests
-            ;; For generating man pages.
-            docbook-xml-4.2
-            docbook-xsl
-            libxslt
-            libxml2)))))
+      (append
+       (list perl-parse-yapp
+             pkg-config)
+       ;; The python-cryptography dependency is needed for the krb5 tests.
+       ;; Since python-cryptography requires Rust, add it conditionally
+       ;; depending on such support.
+       (if (member (%current-system)
+                   (package-transitive-supported-systems
+                    python-cryptography))
+           (list python-cryptography)
+           '())
+       (list python-dnspython
+             python-iso8601
+             python-markdown
+             rpcsvc-proto               ;for 'rpcgen'
+             python-pyasn1              ;for krb5 tests
+             ;; For generating man pages.
+             docbook-xml-4.2
+             docbook-xsl                ;otherwise the man pages are corrupted
+             libxslt
+             libxml2))))))              ;for XML_CATALOG_FILES
+
 
 (define-public samba/fixed
   (package