diff --git a/biology/snpeff/Makefile b/biology/snpeff/Makefile
index ac4b81e11561..a05edccb076e 100644
--- a/biology/snpeff/Makefile
+++ b/biology/snpeff/Makefile
@@ -1,5 +1,5 @@
 PORTNAME=	snpeff
-DISTVERSION=	5.0
+DISTVERSION=	5.1
 CATEGORIES=	biology java python
 MASTER_SITES=	https://snpeff.blob.core.windows.net/versions/
 DISTNAME=	snpEff_latest_core
diff --git a/biology/snpeff/distinfo b/biology/snpeff/distinfo
index decfc79a708d..f57ab2e7febf 100644
--- a/biology/snpeff/distinfo
+++ b/biology/snpeff/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1618847647
-SHA256 (snpeff-5.0/snpEff_latest_core.zip) = 85d907b5dd9e9008a0cf245956e3c9077a31e45f21a1b580d9b98a53fd8dcb9d
-SIZE (snpeff-5.0/snpEff_latest_core.zip) = 45828841
+TIMESTAMP = 1671473460
+SHA256 (snpeff-5.1/snpEff_latest_core.zip) = 919e0595c08e86d1dd82279723c83cb872070244ee4ce0cb3167bde2b272893b
+SIZE (snpeff-5.1/snpEff_latest_core.zip) = 67191760