diff --git a/biology/py-biopython/Makefile b/biology/py-biopython/Makefile
index 57c0832ab7e8..f56438bb0dcd 100644
--- a/biology/py-biopython/Makefile
+++ b/biology/py-biopython/Makefile
@@ -2,7 +2,7 @@
 # $FreeBSD$
 
 PORTNAME=	biopython
-DISTVERSION=	1.77
+DISTVERSION=	1.78
 CATEGORIES=	biology python
 MASTER_SITES=	http://www.biopython.org/DIST/
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
diff --git a/biology/py-biopython/distinfo b/biology/py-biopython/distinfo
index 9738f96f2c8b..6628fec55275 100644
--- a/biology/py-biopython/distinfo
+++ b/biology/py-biopython/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1590688894
-SHA256 (biopython-1.77.tar.gz) = fb1936e9ca9e7af8de1050e84375f23328e04b801063edf0ad73733494d8ec42
-SIZE (biopython-1.77.tar.gz) = 16837021
+TIMESTAMP = 1602768614
+SHA256 (biopython-1.78.tar.gz) = 1ee0a0b6c2376680fea6642d5080baa419fd73df104a62d58a8baf7a8bbe4564
+SIZE (biopython-1.78.tar.gz) = 16895184