diff --git a/converters/py-webencodings/Makefile b/converters/py-webencodings/Makefile
index 4b0df133bb1d..f8c3b035db27 100644
--- a/converters/py-webencodings/Makefile
+++ b/converters/py-webencodings/Makefile
@@ -11,7 +11,7 @@ COMMENT=	Character encoding aliases for legacy web content
 
 LICENSE=	BSD3CLAUSE
 
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	distutils autoplist
 NO_ARCH=	yes
 
diff --git a/databases/py-sqlite3/Makefile b/databases/py-sqlite3/Makefile
index be761e9c88dd..e113296d6d03 100644
--- a/databases/py-sqlite3/Makefile
+++ b/databases/py-sqlite3/Makefile
@@ -20,7 +20,7 @@ LIB_DEPENDS=	libsqlite3.so:databases/sqlite3
 
 PORTSCOUT=	ignore:1
 
-USES=		compiler:c11 python tar:xz
+USES=		compiler:c11 python:2.7+ tar:xz
 USE_PYTHON=	autoplist distutils allflavors
 
 DISTINFO_FILE=	${PORTSDIR}/lang/python${PYTHON_SUFFIX}/distinfo
diff --git a/devel/py-Jinja2/Makefile b/devel/py-Jinja2/Makefile
index 81900c9475d6..2220902af803 100644
--- a/devel/py-Jinja2/Makefile
+++ b/devel/py-Jinja2/Makefile
@@ -20,7 +20,7 @@ TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}markupsafe>=0.23:textproc/py-markupsafe@${P
 
 NO_ARCH=	yes
 .if empty(PKGNAMESUFFIX)
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	autoplist distutils
 .endif
 .if ${PKGNAMESUFFIX} == -doc
diff --git a/devel/py-babel/Makefile b/devel/py-babel/Makefile
index 2b7872754fe1..e96dee8933d4 100644
--- a/devel/py-babel/Makefile
+++ b/devel/py-babel/Makefile
@@ -15,7 +15,7 @@ LICENSE_FILE=	${WRKSRC}/LICENSE
 
 RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytz>0:devel/py-pytz@${PY_FLAVOR}
 
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	autoplist concurrent distutils
 
 NO_ARCH=	yes
diff --git a/devel/py-future/Makefile b/devel/py-future/Makefile
index 8c07fe76c06c..7ec3306509d8 100644
--- a/devel/py-future/Makefile
+++ b/devel/py-future/Makefile
@@ -13,7 +13,7 @@ COMMENT=	Clean single-source support for Python 3 and 2
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	autoplist concurrent distutils
 
 NO_ARCH=	yes
diff --git a/devel/py-game_sdl2/Makefile b/devel/py-game_sdl2/Makefile
index ca6d08279a35..a80b5e877571 100644
--- a/devel/py-game_sdl2/Makefile
+++ b/devel/py-game_sdl2/Makefile
@@ -19,7 +19,7 @@ LIB_DEPENDS=	libpng.so:graphics/png
 # Upstream tends to reroll distfiles before moving under /release/
 PORTSCOUT=	site:http://www.renpy.org/dl/release/
 
-USES=		jpeg python sdl
+USES=		jpeg python:2.7+ sdl
 USE_SDL=	image2 mixer2 ttf2
 USE_PYTHON=	autoplist distutils cython
 EXCLUDE=	gen gen3 PKG-INFO '*.egg-info'
diff --git a/devel/py-ply/Makefile b/devel/py-ply/Makefile
index 67ab48778224..b1e0d5a1e39e 100644
--- a/devel/py-ply/Makefile
+++ b/devel/py-ply/Makefile
@@ -12,7 +12,7 @@ COMMENT=	Python Lex-Yacc
 
 LICENSE=	BSD3CLAUSE
 
-USES=		python
+USES=		python:2.7+
 USES+=		shebangfix
 USE_PYTHON=	autoplist concurrent distutils
 NO_ARCH=	yes
diff --git a/devel/py-pycparser/Makefile b/devel/py-pycparser/Makefile
index 73e23b1380bb..d4451aff59c6 100644
--- a/devel/py-pycparser/Makefile
+++ b/devel/py-pycparser/Makefile
@@ -13,7 +13,7 @@ COMMENT=	C parser in Python
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	autoplist concurrent distutils
 
 NO_ARCH=	yes
diff --git a/devel/py-pytz/Makefile b/devel/py-pytz/Makefile
index 70b76271c68d..da3a8900390e 100644
--- a/devel/py-pytz/Makefile
+++ b/devel/py-pytz/Makefile
@@ -14,7 +14,7 @@ COMMENT=	World Timezone Definitions for Python
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	autoplist distutils
 
 NO_ARCH=	yes
diff --git a/devel/py-setuptools/Makefile b/devel/py-setuptools/Makefile
index 772c7f14ae33..755931347f1f 100644
--- a/devel/py-setuptools/Makefile
+++ b/devel/py-setuptools/Makefile
@@ -17,7 +17,7 @@ LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
 NO_ARCH=	yes
-USES=		python zip
+USES=		python:2.7+ zip
 USE_PYTHON=	allflavors autoplist concurrent distutils
 
 PYDISTUTILS_SETUP=	${PYSETUP}
diff --git a/devel/py-setuptools_scm/Makefile b/devel/py-setuptools_scm/Makefile
index d33aea4049e1..16b878ac950b 100644
--- a/devel/py-setuptools_scm/Makefile
+++ b/devel/py-setuptools_scm/Makefile
@@ -18,7 +18,7 @@ TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest>0:devel/py-pytest@${PY_FLAVOR} \
 		git:devel/git \
 		${PY_MERCURIAL}
 
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	autoplist distutils
 
 NO_ARCH=	yes
diff --git a/devel/py-six/Makefile b/devel/py-six/Makefile
index 6a5f7f1f0bad..14e3d421035b 100644
--- a/devel/py-six/Makefile
+++ b/devel/py-six/Makefile
@@ -15,7 +15,7 @@ LICENSE_FILE=	${WRKSRC}/LICENSE
 
 TEST_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pytest>0:devel/py-pytest@${PY_FLAVOR}
 
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	autoplist concurrent distutils
 
 NO_ARCH=	yes
diff --git a/devel/py-subversion/Makefile b/devel/py-subversion/Makefile
index 8f693364b480..065f6c40a69e 100644
--- a/devel/py-subversion/Makefile
+++ b/devel/py-subversion/Makefile
@@ -9,7 +9,7 @@ COMMENT=	Python bindings for version control system
 
 BUILD_DEPENDS=	${LOCALBASE}/include/py3c.h:devel/py3c
 
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	flavors py3kplist
 
 PORTREVISION_114=	0
diff --git a/devel/scons/Makefile b/devel/scons/Makefile
index d21a28b38152..4d733ee2a8f1 100644
--- a/devel/scons/Makefile
+++ b/devel/scons/Makefile
@@ -15,7 +15,7 @@ LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
 RUN_DEPENDS=	gm4:devel/m4
 
-USES=		python shebangfix
+USES=		python:2.7+ shebangfix
 USE_PYTHON=	autoplist concurrent distutils
 
 NO_ARCH=	yes
diff --git a/dns/py-dnspython/Makefile b/dns/py-dnspython/Makefile
index 88e99c0484ca..a45807bf8d74 100644
--- a/dns/py-dnspython/Makefile
+++ b/dns/py-dnspython/Makefile
@@ -13,7 +13,7 @@ COMMENT=	DNS toolkit for Python
 LICENSE=	ISCL
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-USES=		python zip
+USES=		python:2.7+ zip
 USE_PYTHON=	autoplist concurrent cython distutils
 
 NO_ARCH=	yes
diff --git a/lang/cython/Makefile b/lang/cython/Makefile
index e3ab51b3e366..4f633a24ffcf 100644
--- a/lang/cython/Makefile
+++ b/lang/cython/Makefile
@@ -14,7 +14,7 @@ COMMENT=	Compiler for Writing C Extensions for the Python Language
 LICENSE=	APACHE20
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
 
-USES=		compiler:c11 python
+USES=		compiler:c11 python:2.7+
 USE_PYTHON=	allflavors autoplist concurrent distutils
 
 post-install:
diff --git a/misc/py-tqdm/Makefile b/misc/py-tqdm/Makefile
index 1506edc126c4..134eaf577d9c 100644
--- a/misc/py-tqdm/Makefile
+++ b/misc/py-tqdm/Makefile
@@ -15,7 +15,7 @@ LICENSE_FILE_MIT=	${WRKSRC}/LICENCE
 
 BUILD_DEPENDS=	${PYTHON_PKGNAMEPREFIX}setuptools_scm>=3.4:devel/py-setuptools_scm@${PY_FLAVOR}
 
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	autoplist concurrent distutils
 
 NO_ARCH=	yes
diff --git a/textproc/py-markupsafe/Makefile b/textproc/py-markupsafe/Makefile
index 13653809333c..ca177cd3eb66 100644
--- a/textproc/py-markupsafe/Makefile
+++ b/textproc/py-markupsafe/Makefile
@@ -15,7 +15,7 @@ COMMENT=	Implements XML/HTML/XHTML Markup safe string for Python
 LICENSE=	BSD3CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE.rst
 
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	autoplist concurrent distutils
 
 post-install:
diff --git a/textproc/py-pygments-25/Makefile b/textproc/py-pygments-25/Makefile
index c598f37bc057..ed7d83e26879 100644
--- a/textproc/py-pygments-25/Makefile
+++ b/textproc/py-pygments-25/Makefile
@@ -16,7 +16,7 @@ COMMENT=	Syntax highlighter written in Python
 LICENSE=	BSD2CLAUSE
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	distutils concurrent autoplist
 
 CONFLICTS_INSTALL=	py??-pygments
diff --git a/textproc/py-toml/Makefile b/textproc/py-toml/Makefile
index cf85279d69fe..2ef4da6b61a3 100644
--- a/textproc/py-toml/Makefile
+++ b/textproc/py-toml/Makefile
@@ -13,7 +13,7 @@ COMMENT=	Python library for parsing and creating TOML
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE
 
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	autoplist concurrent distutils
 
 NO_ARCH=	yes
diff --git a/www/py-html5lib/Makefile b/www/py-html5lib/Makefile
index 6e2aeb974c56..04c44ce6dbbd 100644
--- a/www/py-html5lib/Makefile
+++ b/www/py-html5lib/Makefile
@@ -17,7 +17,7 @@ RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}six>0:devel/py-six@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}webencodings>0:converters/py-webencodings@${PY_FLAVOR}
 
 NO_ARCH=	yes
-USES=		python
+USES=		python:2.7+
 USE_PYTHON=	autoplist distutils
 
 .include <bsd.port.mk>
diff --git a/x11-toolkits/py-tkinter/Makefile b/x11-toolkits/py-tkinter/Makefile
index aaa29b85b8ef..8f14609bdab9 100644
--- a/x11-toolkits/py-tkinter/Makefile
+++ b/x11-toolkits/py-tkinter/Makefile
@@ -16,7 +16,7 @@ LICENSE=	PSFL
 
 PORTSCOUT=	ignore:1
 
-USES=		compiler:c11 python tar:xz tk
+USES=		compiler:c11 python:2.7+ tar:xz tk
 USE_PYTHON=	distutils autoplist allflavors
 
 DIST_SUBDIR=	python